Each scan finds different items, and only you can make the decision if you should delete them (or not) from your system, and as such, it is not safe to just blindly delete files.
In particular, the File Finder scan is designed to find files over a certain size (default is 50 MB) for you to investigate what is taking up space on your hard disk, and it is permissible that many (if not all) of those files you might want to keep, but we present them for you to investigate further.